Peptide library / Skin & aging / GHK-Cu
GHK-Cu
A natural copper-binding tripeptide used widely in skin creams and promoted as an injectable.
Full analysis available. GHK-Cu is under FDA compounding review, and we cover it in depth with the committee vote and our Peptide Evidence Index. Read the full GHK-Cu analysis →
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Skin firmness and wrinkles, topicalSmall human studies
- Wound healingAnimals
- Hair growth, claimedSmall human studies
How it is thought to work
GHK is a three amino acid fragment of collagen that binds copper and is reported to signal skin cells to make collagen and repair tissue.
What the evidence shows
Small studies of creams reported modest improvements in skin density and wrinkles. Evidence for injected use is limited to animals and cell studies.
Safety and unknowns
Topical use is generally well tolerated. Injected copper peptides have limited safety data.
Regulatory status
Sold as a cosmetic ingredient. Not FDA-approved as a drug. See our full GHK-Cu profile.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.