Peptide library / Skin & aging / FOXO4-DRI
FOXO4-DRI
A designer peptide that triggers aged senescent cells to self-destruct, shown in mice.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Clearance of senescent cellsAnimals
- Fitness and kidney function in aged miceAnimals
How it is thought to work
FOXO4-DRI blocks the interaction between FOXO4 and p53 inside senescent cells, letting p53 trigger cell death.
What the evidence shows
A 2017 study in mice reported improved fur density, activity and kidney function. No human trials have been reported.
Safety and unknowns
Human safety and effectiveness are unknown.
Regulatory status
Not approved. Research only.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.