Peptide library / Heart & blood / Serelaxin
Serelaxin
Recombinant human relaxin-2, a pregnancy hormone tested in acute heart failure.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Acute heart failureLarge trials
How it is thought to work
Serelaxin widens blood vessels and has anti-fibrotic effects, thought to ease the load on the heart.
What the evidence shows
RELAX-AHF showed symptom benefit, but the confirmatory RELAX-AHF-2 trial in 2018 did not reduce cardiovascular death.
Safety and unknowns
Low blood pressure was the main side effect.
Regulatory status
Not approved. Development ended.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Heart & blood
Terlipressin
FDA-approvedA vasopressin prodrug used for kidney failure in advanced liver disease.
Ularitide
In clinical trialsA kidney-derived natriuretic peptide tested in acute heart failure and found not to help.
Selepressin
In clinical trialsA selective vasopressin V1a agonist tested in septic shock.
General information, not medical advice. Do not buy or inject unregulated peptides.