Peptide library / Heart & blood / Ularitide
Ularitide
A kidney-derived natriuretic peptide tested in acute heart failure and found not to help.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Acute heart failureLarge trials
How it is thought to work
Ularitide acts on the same receptor as atrial natriuretic peptide in the kidney to promote salt and water loss.
What the evidence shows
In the TRUE-AHF trial of over 2,000 patients, infusion did not reduce cardiovascular death compared with placebo.
Safety and unknowns
Low blood pressure was more frequent than with placebo.
Regulatory status
Not approved. Development ended.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.