Peptide library / Heart & blood / Rusfertide
Rusfertide
An investigational hepcidin mimetic injected under the skin for polycythemia vera.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Polycythemia veraLarge trials
How it is thought to work
Rusfertide copies hepcidin, the hormone that limits iron availability, which in turn restrains overproduction of red blood cells.
What the evidence shows
The phase 3 VERIFY trial met its main endpoint, with fewer phlebotomies needed than placebo.
Safety and unknowns
Injection site reactions, fatigue and low iron have been reported.
Regulatory status
Not approved at the time of writing. Regulatory filings are under way.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.