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Peptide library / Skin & aging / Palmitoyl tripeptide-5

Cosmetic and topicalSkin & aging

Palmitoyl tripeptide-5

A three amino acid peptide marketed to stimulate collagen production.

Body system
Skin & aging
Status
Cosmetic and topical
Strongest evidence
Lab
Also known as
Syn-Coll, Pal-KVK

Effects studied or claimed

What it is used or promoted for, and where each effect has actually been seen

  • Improve skin firmness, topicalLab

How it is thought to work

It is described as releasing TGF-beta, a growth factor that boosts collagen synthesis.

What the evidence shows

Support is mostly from manufacturer data.

Safety and unknowns

Well tolerated.

Regulatory status

Cosmetic ingredient, not a drug.

Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.

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General information, not medical advice. Do not buy or inject unregulated peptides.