Peptide library / Skin & aging / Palmitoyl pentapeptide-4
Palmitoyl pentapeptide-4
A five amino acid fragment of collagen with a fatty acid tail, the best-studied anti-wrinkle peptide.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Reduce wrinkle depth, topicalSmall human studies
How it is thought to work
The fragment imitates the product released when collagen is broken down, signaling skin cells to make new collagen. The fatty acid tail helps it enter skin.
What the evidence shows
A small double-blind study of a cream with the peptide reported smaller wrinkles on the face after 12 weeks. Most data come from manufacturer-sponsored work.
Safety and unknowns
Well tolerated in topical form, with rare irritation.
Regulatory status
Cosmetic ingredient, not a drug.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Skin & aging
Palmitoyl tetrapeptide-7
Cosmetic and topicalA four amino acid fragment of an antibody, used to calm skin inflammation signals.
Palmitoyl tripeptide-1
Cosmetic and topicalGHK with a fatty acid tail to help it cross the skin barrier.
Palmitoyl hexapeptide-12
Cosmetic and topicalAn elastin-derived peptide marketed to improve skin firmness.
General information, not medical advice. Do not buy or inject unregulated peptides.