Peptide library / Brain & sleep / Epitalon
Epitalon
A four amino acid peptide promoted for sleep and longevity, studied mainly by one research group.
Full analysis available. Epitalon is under FDA compounding review, and we cover it in depth with the committee vote and our Peptide Evidence Index. Read the full Epitalon analysis →
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Melatonin and sleep regulationSmall human studies
- Longevity in animalsAnimals
- Telomere length in cellsLab
How it is thought to work
Epitalon is a synthetic version of a peptide from the pineal gland and is reported to affect melatonin release and telomerase activity.
What the evidence shows
Most work comes from the St. Petersburg Institute of Bioregulation and Gerontology. Independent replication is lacking.
Safety and unknowns
Safety in people has not been tested in modern controlled trials.
Regulatory status
Not FDA-approved. See our full Epitalon profile.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.