Peptide library / Brain & sleep / Nerinetide
Nerinetide
A 20 amino acid peptide tested to protect brain cells during stroke.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Neuroprotection in ischemic strokeLarge trials
How it is thought to work
Nerinetide disrupts the interaction of PSD-95 with receptors that drive nerve cell death after loss of blood flow.
What the evidence shows
In the ESCAPE-NA1 trial there was no overall benefit, but patients who did not receive alteplase appeared to benefit. A follow-up trial is testing this finding.
Safety and unknowns
Allergic-type reactions occurred in a few patients.
Regulatory status
Not approved. Further trials are ongoing.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.