Peptide library / Brain & sleep / Delta sleep-inducing peptide
Delta sleep-inducing peptide
A nine amino acid peptide first isolated from rabbit brain in the 1970s and tested for insomnia.
Full analysis available. Delta sleep-inducing peptide is under FDA compounding review, and we cover it in depth with the committee vote and our Peptide Evidence Index. Read the full Delta sleep-inducing peptide analysis →
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- InsomniaSmall human studies
- Opioid withdrawal symptomsSmall human studies
How it is thought to work
DSIP was named for its effect on slow-wave sleep in rabbits, but its receptor and physiological role in people remain unclear.
What the evidence shows
A few small human studies from the 1980s and early 1990s suggested better sleep, with mixed results. No recent high-quality trials exist.
Safety and unknowns
Short half-life, and human safety data are old and limited.
Regulatory status
Not FDA-approved. See our full DSIP profile.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.