Peptide library / Heart & blood / Apelin-13
Apelin-13
A 13 amino acid peptide that strengthens the heart and widens blood vessels, studied in heart failure.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Heart contraction in heart failureSmall human studies
- Muscle agingAnimals
How it is thought to work
Apelin binds the APJ receptor on heart muscle and vessel cells, increasing contraction and dilating arteries, which also appears in muscle aging.
What the evidence shows
Infusions in people with heart failure increased cardiac output. The peptide is broken down in minutes, so longer-acting versions are being developed.
Safety and unknowns
Short half-life limits use.
Regulatory status
Not approved. Research tool and drug target.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Heart & blood
Balixafortide
In clinical trialsA cyclic peptide CXCR4 blocker tested with chemotherapy in breast cancer.
Bivalirudin
FDA-approvedA 20 amino acid blood thinner based on leech hirudin, used during heart procedures.
Angiotensin II
FDA-approvedA synthetic form of the body's own blood pressure hormone, used in septic shock.
General information, not medical advice. Do not buy or inject unregulated peptides.