Peptide library / Digestive & weight / Plecanatide
Plecanatide
A 16 amino acid guanylate cyclase-C agonist for constipation and irritable bowel syndrome.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Chronic idiopathic constipationFDA approved
- Irritable bowel syndrome with constipationFDA approved
How it is thought to work
Plecanatide is a copy of uroguanylin, a natural gut hormone, and raises fluid secretion and transit in the intestine.
What the evidence shows
Phase 3 trials showed improvement in the number of complete spontaneous bowel movements compared with placebo.
Safety and unknowns
Diarrhea is the main side effect. It carries a boxed warning against use in young children.
Regulatory status
FDA-approved as Trulance in 2017.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.