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Peptide library / Digestive & weight / Petrelintide

In clinical trialsDigestive & weight

Petrelintide

An investigational long-acting amylin analog from Zealand Pharma and Roche.

Body system
Digestive & weight
Status
In clinical trials
Strongest evidence
Small human studies
Also known as
ZP8396

Effects studied or claimed

What it is used or promoted for, and where each effect has actually been seen

  • Weight loss in obesitySmall human studies

How it is thought to work

Petrelintide mimics amylin to increase fullness, and aims to deliver weight loss with fewer gastrointestinal effects than GLP-1 drugs.

What the evidence shows

Early and mid-stage studies showed weight loss with a favorable tolerability profile, but data are limited to phase 1 and 2.

Safety and unknowns

Gastrointestinal effects were reported. Long-term safety is unknown.

Regulatory status

Not approved. Development continues in phase 2.

Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.

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General information, not medical advice. Do not buy or inject unregulated peptides.