Peptide library / Bones & muscles / Parathyroid hormone 1-84
Parathyroid hormone 1-84
The full-length parathyroid hormone, once used for hypoparathyroidism and now withdrawn.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- HypoparathyroidismFDA approved
How it is thought to work
Natpara replaced the missing hormone in people whose parathyroid glands do not make enough, raising blood calcium.
What the evidence shows
The REPLACE trial showed more patients could reduce calcium and vitamin D supplements while keeping blood calcium stable.
Safety and unknowns
Osteosarcoma was seen in rats, and the label carried a boxed warning. Low and high calcium both occurred.
Regulatory status
FDA-approved in 2015. The manufacturer discontinued it at the end of 2024.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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Palopegteriparatide
FDA-approvedA long-acting prodrug of parathyroid hormone given once daily for hypoparathyroidism.
General information, not medical advice. Do not buy or inject unregulated peptides.