Peptide library / Bones & muscles / TB-500
TB-500
A lab-made fragment of a natural repair protein promoted for tissue healing and sports injury recovery.
Full analysis available. TB-500 is under FDA compounding review, and we cover it in depth with the committee vote and our Peptide Evidence Index. Read the full TB-500 analysis →
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Tendon and muscle repairAnimals
- Wound healingAnimals
- Heart tissue repairAnimals
How it is thought to work
TB-500 corresponds to the actin-binding region of thymosin beta-4 and is thought to help cells migrate toward injured tissue.
What the evidence shows
Evidence comes from animal studies, most of them using full-length thymosin beta-4. There are no controlled human trials of TB-500 itself.
Safety and unknowns
Safety in people is unknown. It is prohibited in sport.
Regulatory status
Not FDA-approved. See our full TB-500 profile for the 2026 advisory committee review.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Bones & muscles
Teriparatide
FDA-approvedThe first 34 amino acids of parathyroid hormone, a bone-building osteoporosis drug.
Thymosin beta-4
In clinical trialsA 43 amino acid protein present in nearly all human cells, studied for eye, heart and skin repair.
PEG-MGF
Wellness and performanceA long-acting version of mechano growth factor, studied only in animals.
General information, not medical advice. Do not buy or inject unregulated peptides.