Peptide library / Hormones & metabolism / MOTS-c
MOTS-c
A 16 amino acid peptide encoded by mitochondrial DNA, studied for metabolism and exercise capacity.
Full analysis available. MOTS-c is under FDA compounding review, and we cover it in depth with the committee vote and our Peptide Evidence Index. Read the full MOTS-c analysis →
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Improved insulin sensitivityAnimals
- Exercise performanceAnimals
- Lifespan, studiedAnimals
How it is thought to work
MOTS-c is reported to activate AMPK, a cellular energy sensor, and to improve glucose handling in muscle in animals.
What the evidence shows
Mouse studies reported protection from diet-induced obesity and better exercise capacity. Human data are limited to observational findings and small pilot studies.
Safety and unknowns
Human safety is largely untested. Unregulated products vary in quality.
Regulatory status
Not FDA-approved. See our full MOTS-c profile for the 2026 advisory committee review.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.