Peptide library / Immune & defense / Voclosporin
Voclosporin
A modified cyclosporine for lupus nephritis.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Lupus nephritisFDA approved
How it is thought to work
Voclosporin is a calcineurin inhibitor with a more predictable effect than cyclosporine.
What the evidence shows
The AURORA trials showed more patients reached a kidney response when added to standard therapy.
Safety and unknowns
A boxed warning covers malignancies and serious infections. Kidney function and blood pressure need monitoring.
Regulatory status
FDA-approved as Lupkynis in 2021.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.