Peptide library / Brain & sleep / Trofinetide
Trofinetide
A synthetic analog of a small brain peptide approved for Rett syndrome.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Rett syndrome in children and adultsFDA approved
How it is thought to work
Trofinetide is a version of glycine-proline-glutamate, a fragment of IGF-1, and is thought to support synapse function and reduce inflammation.
What the evidence shows
A phase 3 trial reported improvement in caregiver-reported and clinician-rated measures compared with placebo.
Safety and unknowns
Diarrhea and vomiting are very common and can cause dehydration.
Regulatory status
FDA-approved as Daybue in 2023.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Brain & sleep
Ziconotide
FDA-approvedA synthetic cone snail toxin injected into the spinal fluid for severe chronic pain.
Cerebrolysin
Wellness and performanceA mixture of peptides made from pig brain, used in parts of Europe and Asia after stroke and head injury.
Semax
Wellness and performanceA seven amino acid peptide derived from ACTH, used as a nasal spray in Russia after stroke.
General information, not medical advice. Do not buy or inject unregulated peptides.