Peptide library / Immune & defense / Pexiganan
Pexiganan
A magainin-like peptide cream tested for infected diabetic foot ulcers.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Infected diabetic foot ulcersLarge trials
How it is thought to work
Pexiganan is a synthetic analog of a frog skin antimicrobial peptide that disrupts bacterial membranes.
What the evidence shows
Phase 3 trials in the 1990s were comparable to oral antibiotics, but the FDA did not approve it. New phase 3 trials were later run.
Safety and unknowns
Local irritation was the main side effect.
Regulatory status
Not approved.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.