Peptide library / Brain & sleep / PE-22-28
PE-22-28
A short synthetic peptide studied in mice as a fast-acting antidepressant.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Depression-like behavior in miceAnimals
- Mood and focus, promotedLab
How it is thought to work
PE-22-28 is a shortened version of spadin and blocks the TREK-1 potassium channel, which in mice speeds up the response to antidepressant treatment.
What the evidence shows
Mouse studies reported antidepressant-like effects within days. There are no human trials.
Safety and unknowns
Human safety is unknown. Products sold online are not quality-controlled.
Regulatory status
Not approved. Sold as a research chemical.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.