Peptide library / Heart & blood / Nesiritide
Nesiritide
A recombinant B-type natriuretic peptide once widely used in acute heart failure.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Acute decompensated heart failureFDA approved
How it is thought to work
Nesiritide relaxes blood vessels and promotes salt and water excretion, lowering pressure in the heart.
What the evidence shows
The large ASCEND-HF trial found no clear improvement in death or rehospitalization, and use has declined.
Safety and unknowns
Low blood pressure is common and can limit dosing.
Regulatory status
FDA-approved as Natrecor in 2001.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.