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Peptide library / Sexual & reproductive / Nafarelin

FDA-approvedSexual & reproductive

Nafarelin

A nasal-spray GnRH agonist for endometriosis and early puberty.

Body system
Sexual & reproductive
Status
FDA-approved
Strongest evidence
FDA approved
Also known as
Synarel

Effects studied or claimed

What it is used or promoted for, and where each effect has actually been seen

  • EndometriosisFDA approved
  • Central precocious pubertyFDA approved

How it is thought to work

Nafarelin suppresses the pituitary-gonad axis after an initial surge, lowering estrogen.

What the evidence shows

Trials show pain relief similar to other GnRH agonists.

Safety and unknowns

Hot flushes, vaginal dryness and bone loss with long use.

Regulatory status

FDA-approved as Synarel in 1990.

Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.

Sources

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General information, not medical advice. Do not buy or inject unregulated peptides.