Peptide library / Bones & muscles / Mechano growth factor
Mechano growth factor
A splice variant of IGF-1 released by muscle after stretch and damage, marketed for muscle growth.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Muscle repair after damageAnimals
- Muscle growth, promotedLab
How it is thought to work
MGF is thought to activate muscle satellite cells, the stem cells that repair and build muscle, soon after exercise or injury.
What the evidence shows
Work in mice and cell culture supports a role in muscle repair. The natural peptide is broken down within minutes, and human intervention data are missing.
Safety and unknowns
Safety in people is unknown. It is prohibited in sport.
Regulatory status
Not approved. Sold as a research chemical.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
More in Bones & muscles
Osteogenic growth peptide
Wellness and performanceA 14 amino acid peptide found in blood that stimulates bone formation in animals.
Palopegteriparatide
FDA-approvedA long-acting prodrug of parathyroid hormone given once daily for hypoparathyroidism.
Irisin
Wellness and performanceA hormone-like protein released by muscle during exercise, with a contested role in people.
General information, not medical advice. Do not buy or inject unregulated peptides.