Peptide library / Skin & aging / Acetyl tetrapeptide-5
Acetyl tetrapeptide-5
A four amino acid peptide used in eye creams for puffiness and dark circles.
Effects studied or claimed
What it is used or promoted for, and where each effect has actually been seen
- Reduce under-eye puffiness, topicalLab
How it is thought to work
It is said to inhibit enzymes that drive fluid build-up and glycation under the eyes.
What the evidence shows
Small manufacturer studies report modest changes in bags under the eyes.
Safety and unknowns
Well tolerated.
Regulatory status
Cosmetic ingredient, not a drug.
Regulatory status changes quickly. This entry was last reviewed on 27 October 2026. Confirm current status with the FDA before relying on it.
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General information, not medical advice. Do not buy or inject unregulated peptides.